Survival kinases in ischemic preconditioning and postconditioning
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چکیده
منابع مشابه
Survival kinases in ischemic preconditioning and postconditioning.
Despite nearly twenty years of research into the field of ischemic preconditioning, the actual mechanism of protection remains unclear. However, much progress has been made in elucidating the signal transduction pathways that convey the extracellular signal initiated by the preconditioning stimulus to the intracellular targets of cardioprotection, with many of these pathways involving the activ...
متن کاملNeuroproctective effects of ischemic tolerance (preconditioning) and postconditioning.
Elucidation of the endogenous cell survival pathways involved in ischemic tolerance (preconditioning) and postconditioning has significant clinical implications for preventing neuronal damage in susceptible patients. Ischemic tolerance is a phenomenon in which the brain protects itself against future injury by adapting to low doses of noxious insults. Ischemic postconditioning is defined as bri...
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Acid-sensing ion channels, ASICs, are proton-gated cation channels widely expressed in peripheral sensory neurons and in neurons of the central nervous system that play an important role in a variety of physiological and pathological processes. To further confirm the role played by ASIC1a in cerebral ischemia, here we examined the involvement of this channel in two endogenous recently character...
متن کاملPreconditioning and Postconditioning
Joseph T. McCabe1, Michael W. Bentley2 and Joseph C. O’Sullivan2 1Department of Anatomy, Physiology & Genetics, and The Center for Neuroscience & Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 2U.S. Army Graduate School of Anesthesia Nursing, Graduate School, AMEDD Center and School, Academy of Health Sciences, Fort Sam Houston, San Antonio, Texa...
متن کاملCombined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning.
Ischemic postconditioning (PostC) and perconditioning (PerC) provide practical methods for protecting the heart against ischemia-reperfusion (I/R) injury, but their combined effects have not been studied in detail. Using an in vivo rat I/R model, we tested 1) whether additive effects were produced when local PostC was preceded by varying doses of remote PerC, and whether the optimal PostC+PerC ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2006
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2006.01.017